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Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: a study matched for T- and N- classification

Smad4 protein, whose gene is coded at chromosome 18q21.1, is an important tumour suppressor that mediates transforming growth factor-beta. It has been reported that inactivation of the Smad4 gene and allelic loss of chromosome 18q correlate with liver metastasis and poorer prognosis in colorectal ca...

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Bibliografiske detaljer
Main Authors: Tanaka, T, Watanabe, T, Kazama, Y, Tanaka, J, Kanazawa, T, Kazama, S, Nagawa, H
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360736/
https://ncbi.nlm.nih.gov/pubmed/17088901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603460
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