The Lys234Arg Substitution in the Enzyme SHV-72 Is a Determinant for Resistance to Clavulanic Acid Inhibition

The new β-lactamase SHV-72 was isolated from clinical Klebsiella pneumoniae INSRA1229, which exhibited the unusual association of resistance to the amoxicillin-clavulanic acid combination (MIC, 64 μg/ml) and susceptibility to cephalosporins, aztreonam, and imipenem. SHV-72 (pI 7.6) harbored the thre...

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Bibliografiska uppgifter
Huvudupphovsmän: Mendonça, Nuno, Manageiro, Vera, Robin, Frédéric, Salgado, M. José, Ferreira, Eugénia, Caniça, Manuela, Bonnet, Richard
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346665/
https://ncbi.nlm.nih.gov/pubmed/18316518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01381-07
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