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Chromatin-Bound p53 Anchors Activated Smads and the mSin3A Corepressor To Confer Transforming Growth Factor β-Mediated Transcription Repression

In hepatic cells, Smad and SnoN proteins converge with p53 to repress transcription of AFP, an oncodevelopmental tumor marker aberrantly reactivated in hepatoma cells. Using p53- and SnoN-depleted hepatoma cell clones, we define a mechanism for repression mediated by this novel transcriptional partn...

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Hlavní autoři: Wilkinson, Deepti Srinivas, Tsai, Wen-Wei, Schumacher, Maria A., Barton, Michelle Craig
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268392/
https://ncbi.nlm.nih.gov/pubmed/18212064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01442-07
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