NCX-4040, a nitric oxide-releasing aspirin, sensitizes drug-resistant human ovarian xenograft tumors to cisplatin by depletion of cellular thiols

BACKGROUND: Ovarian carcinoma is the leading cause of mortality among gynecological cancers in the world. The high mortality rate is associated with lack of early diagnosis and development of drug resistance. The antitumor efficacy and mechanism of NCX-4040, a nitric oxide-releasing aspirin derivati...

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Detalhes bibliográficos
Main Authors: Bratasz, Anna, Selvendiran, Karuppaiyah, Wasowicz, Tomasz, Bobko, Andrey, Khramtsov, Valery V, Ignarro, Louis J, Kuppusamy, Periannan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267444/
https://ncbi.nlm.nih.gov/pubmed/18302761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-6-9
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