Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy

BACKGROUND: Unlike CD4+ T cells, HIV-1 infected macrophages exhibit extended life span even upon stress, consistent with their in vivo role as long-lived HIV-1 reservoirs. RESULTS: Here, we demonstrate that PI3K/Akt inhibitors, including clinically available Miltefosine, dramatically reduced HIV-1 p...

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Detalhes bibliográficos
Main Authors: Chugh, Pauline, Bradel-Tretheway, Birgit, Monteiro-Filho, Carlos MR, Planelles, Vicente, Maggirwar, Sanjay B, Dewhurst, Stephen, Kim, Baek
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265748/
https://ncbi.nlm.nih.gov/pubmed/18237430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-5-11
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