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An E2F1-Dependent Gene Expression Program That Determines the Balance Between Proliferation and Cell Death
The Rb/E2F pathway regulates the expression of genes essential for cell proliferation but that also trigger apoptosis. During normal proliferation, PI3K/Akt signaling blocks E2F1 induced apoptosis, thus serving to balance proliferation and death. We now identify a subset of E2F1 target genes that ar...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2243238/ https://ncbi.nlm.nih.gov/pubmed/18167336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2007.11.031 |
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