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Repair of DNA double-strand breaks within the (GAA•TTC)(n) sequence results in frequent deletion of the triplet-repeat sequence
Friedreich ataxia is caused by an expanded (GAA•TTC)(n) sequence, which is unstable during intergenerational transmission and in most patient tissues, where it frequently undergoes large deletions. We investigated the effect of DSB repair on instability of the (GAA•TTC)(n) sequence. Linear plasmids...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2241870/ https://ncbi.nlm.nih.gov/pubmed/18045804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm1066 |
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