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Synthesis of (–)-Indolizidine 167B based on domino hydroformylation/cyclization reactions

The synthesis of (–)-Indolizidine 167B has been achieved from optically active (R)-3-(pyrrol-1-yl)hex-1-ene. The key step is a highly regioselective hydroformylation reaction and a one-pot intramolecular cyclization providing a general approach to the indolizine nucleus.

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Detalhes bibliográficos
Main Authors: Guazzelli, Giuditta, Lazzaroni, Raffaello, Settambolo, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2241606/
https://ncbi.nlm.nih.gov/pubmed/18197967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1860-5397-4-2
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