Discovery of a novel class of highly conserved vaccine antigens using genomic scale antigenic fingerprinting of pneumococcus with human antibodies

Pneumococcus is one of the most important human pathogens that causes life-threatening invasive diseases, especially at the extremities of age. Capsular polysaccharides (CPSs) are known to induce protective antibodies; however, it is not feasible to develop CPS-based vaccines that cover all of the 9...

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Main Authors: Giefing, Carmen, Meinke, Andreas L., Hanner, Markus, Henics, Tamás, Minh, Duc Bui, Gelbmann, Dieter, Lundberg, Urban, Senn, Beatrice M., Schunn, Michael, Habel, Andre, Henriques-Normark, Birgitta, Örtqvist, Åke, Kalin, Mats, von Gabain, Alexander, Nagy, Eszter
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234372/
https://ncbi.nlm.nih.gov/pubmed/18166586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071168
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