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Conversion of the prodrug etoposide phosphate to etoposide in gastric juice and bile.

Etoposide phosphate is a water-soluble prodrug of etoposide. It was expected that this prodrug could be used to overcome the solubility limitations and erratic bioavailability of oral etoposide. To investigate the possibility of prodrug conversion to etoposide within the gastrointestinal lumen, etop...

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Détails bibliographiques
Auteurs principaux: de Jong, R. S., Slijfer, E. A., Uges, D. R., Mulder, N. H., de Vries, E. G.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1997
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2228182/
https://ncbi.nlm.nih.gov/pubmed/9400945
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