Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability

Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. Here we report that disrupting the Slc4a10 gene, which encodes the Na(+)-coupled Cl(−)–HCO(3)(−) exchanger Slc4a10 (NCBE), drastically reduces brain ventricle volume and protects against fatal epi...

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Main Authors: Jacobs, Stefan, Ruusuvuori, Eva, Sipilä, Sampsa T., Haapanen, Aleksi, Damkier, Helle H., Kurth, Ingo, Hentschke, Moritz, Schweizer, Michaela, Rudhard, York, Laatikainen, Linda M., Tyynelä, Jaana, Praetorius, Jeppe, Voipio, Juha, Hübner, Christian A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2008
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224208/
https://ncbi.nlm.nih.gov/pubmed/18165320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705487105
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