Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability

Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. Here we report that disrupting the Slc4a10 gene, which encodes the Na(+)-coupled Cl(−)–HCO(3)(−) exchanger Slc4a10 (NCBE), drastically reduces brain ventricle volume and protects against fatal epi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Jacobs, Stefan, Ruusuvuori, Eva, Sipilä, Sampsa T., Haapanen, Aleksi, Damkier, Helle H., Kurth, Ingo, Hentschke, Moritz, Schweizer, Michaela, Rudhard, York, Laatikainen, Linda M., Tyynelä, Jaana, Praetorius, Jeppe, Voipio, Juha, Hübner, Christian A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224208/
https://ncbi.nlm.nih.gov/pubmed/18165320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705487105
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