Inactivation of the UNC5C netrin-1 receptor is associated with tumor progression in colorectal malignancies

BACKGROUND & AIMS: The UNC5H netrin-1 receptors (UNC5H1-3, or UNC5A-C) belong to the functional dependence receptors family that share the ability to induce apoptosis in the absence of their ligands. Such a trait has been hypothesized to confer a tumor suppressor activity. Indeed, cells harborin...

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Main Authors: Bernet, Agnès, Mazelin, Laetitia, Coissieux, Marie-May, Gadot, Nicolas, Ackerman, Susan L., Scoazec, Jean-Yves, Mehlen, Patrick
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211510/
https://ncbi.nlm.nih.gov/pubmed/17967459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2007.08.009
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