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Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit

The potassium channel accessory subunit KChIP2 associates with Kv4.2 channels in the cardiac myocyte and is involved in the regulation of the transient outward current (I(to)) during the early phase of repolarization of the action potential. As a first step to biophysically probe the mechanism of KC...

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Bibliographic Details
Main Authors: Rajagopal, Sudarshan, Kent, Stephen B.H.
Format: Artigo
Language:Inglês
Published: Wiley-Blackwell 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206977/
https://ncbi.nlm.nih.gov/pubmed/17660260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072876107
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