Differential cytotoxicity of [123I]IUdR, [125I]IUdR and [131I]IUdR to human glioma cells in monolayer or spheroid culture: effect of proliferative heterogeneity and radiation cross-fire.

Radioiodinated iododeoxyuridine (IUdR) is a novel, cycle-specific agent that has potential for the treatment of residual malignant glioma after surgery. As only cells in S-phase incorporate IUdR into DNA, a major limitation to this therapy is likely to be proliferative heterogeneity of the tumour ce...

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Hauptverfasser: Neshasteh-Riz, A., Mairs, R. J., Angerson, W. J., Stanton, P. D., Reeves, J. R., Rampling, R., Owens, J., Wheldon, T. E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1998
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151303/
https://ncbi.nlm.nih.gov/pubmed/9472632
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