Nitrogen mustard up-regulates Bcl-2 and GSH and increases NTP and PCr in HT-29 colon cancer cells.

We hypothesized that unexplained increases in nucleoside triphosphates (NTP) observed by 31P magnetic resonance spectroscopy (MRS) after treatment of tumours by DNA-damaging agents were related to chemotherapy-induced up-regulation of the bcl-2 gene and DNA damage prevention and repair processes. To...

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Bibliographic Details
Main Authors: Boddie, A. W., Constantinou, A., Williams, C., Reed, A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150204/
https://ncbi.nlm.nih.gov/pubmed/9652754
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