Progressive CD4(+) central–memory T cell decline results in CD4(+) effector–memory insufficiency and overt disease in chronic SIV infection

Primary simian immunodeficiency virus (SIV) infections of rhesus macaques result in the dramatic depletion of CD4(+) CCR5(+) effector–memory T (T(EM)) cells from extra-lymphoid effector sites, but in most infections, an increased rate of CD4(+) memory T cell proliferation appears to prevent collapse...

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Main Authors: Okoye, Afam, Meier-Schellersheim, Martin, Brenchley, Jason M., Hagen, Shoko I., Walker, Joshua M., Rohankhedkar, Mukta, Lum, Richard, Edgar, John B., Planer, Shannon L., Legasse, Alfred, Sylwester, Andrew W., Piatak, Michael, Lifson, Jeffrey D., Maino, Vernon C., Sodora, Donald L., Douek, Daniel C., Axthelm, Michael K., Grossman, Zvi, Picker, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118701/
https://ncbi.nlm.nih.gov/pubmed/17724130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20070567
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