Detection of Chromosomal Structural Alterations in Single Cells by SNP Arrays: A Systematic Survey of Amplification Bias and Optimized Workflow

BACKGROUND: In single-cell human genome analysis using whole-genome amplified product, a strong amplification bias involving allele dropout and preferential amplification hampers the quality of results. Using an oligonucleotide single nucleotide polymorphism (SNP) array, we systematically examined t...

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Main Authors: Iwamoto, Kazuya, Bundo, Miki, Ueda, Junko, Nakano, Yoko, Ukai, Wataru, Hashimoto, Eri, Saito, Toshikazu, Kato, Tadafumi
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2007
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111048/
https://ncbi.nlm.nih.gov/pubmed/18074030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001306
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