Detection of Chromosomal Structural Alterations in Single Cells by SNP Arrays: A Systematic Survey of Amplification Bias and Optimized Workflow

BACKGROUND: In single-cell human genome analysis using whole-genome amplified product, a strong amplification bias involving allele dropout and preferential amplification hampers the quality of results. Using an oligonucleotide single nucleotide polymorphism (SNP) array, we systematically examined t...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Iwamoto, Kazuya, Bundo, Miki, Ueda, Junko, Nakano, Yoko, Ukai, Wataru, Hashimoto, Eri, Saito, Toshikazu, Kato, Tadafumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2007
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2111048/
https://ncbi.nlm.nih.gov/pubmed/18074030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001306
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky