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Agonist-induced closure of constitutively open γ-aminobutyric acid channels with mutated M2 domains
Ligand-gated ion channels display a fundamental property—channels remain virtually closed at rest and open upon agonist binding. Here we show that substituting alanines for either of two amino acid residues (T314 or L317) in the M2 region of the γ-aminobutyric acid (GABA) ρ1 subunit results in spont...
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| Главные авторы: | , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences of the USA
1997
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC21077/ https://ncbi.nlm.nih.gov/pubmed/9177245 |
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