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Site-directed mutagenesis of amino acid residues of protein phosphatase 1 involved in catalysis and inhibitor binding

Site-directed mutagenesis of selected residues of mammalian protein phosphatase 1 (PP-1) has been carried out to further define the mechanism of catalysis, activation by divalent cations, and inhibition by toxins and inhibitory proteins. Mutation of active site residues predicted to bind metals (N12...

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Autori principali: Huang, Hsien-Bin, Horiuchi, Atsuko, Goldberg, Jonathan, Greengard, Paul, Nairn, Angus C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC20473/
https://ncbi.nlm.nih.gov/pubmed/9108010
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