Glia-dependent TGF-β signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis

Autoimmune encephalomyelitis, a mouse model for multiple sclerosis, is characterized by the activation of immune cells, demyelination of axons in the CNS, and paralysis. We found that TGF-β1 synthesis in glial cells and TGF-β–induced signaling in the CNS were activated several days before the onset...

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Detalhes bibliográficos
Main Authors: Luo, Jian, Ho, Peggy P., Buckwalter, Marion S., Hsu, Tiffany, Lee, Lowen Y., Zhang, Hui, Kim, Dae-Kee, Kim, Seong-Jin, Gambhir, Sanjiv S., Steinman, Lawrence, Wyss-Coray, Tony
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040317/
https://ncbi.nlm.nih.gov/pubmed/17965773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31763
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