A Conformational Transition in the Adenylyl Cyclase Catalytic Site Yields Different Binding Modes for Ribosyl-Modified and Unmodified Nucleotide Inhibitors

Adenylyl cyclases (ACs) are promising pharmacological targets for treating heart failure, cancer and psychosis. Ribose-substituted nucleotides have been reported as a potent family of AC inhibitors. In silico analysis of the docked conformers of such nucleotides in AC permits assembly of a consisten...

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Autores principales: Wang, Jenna L., Guo, Jian-Xin, Zhang, Qi-Yuan, Wu, Jay J-Q., Seifert, Roland, Lushington, Gerald H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2023969/
https://ncbi.nlm.nih.gov/pubmed/17329110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.02.014
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