STRUCTURE OF A HIGH-AFFINITY “MIMOTOPE” PEPTIDE BOUND TO HIV-1-NEUTRALIZING ANTIBODY b12 EXPLAINS ITS INABILITY TO ELICIT gp120 CROSS-REACTIVE ANTIBODIES

The human antibody b12 recognizes a discontinuous epitope on gp120 and is one of the rare monoclonal antibodies that neutralize a broad range of primary HIV-1 isolates. We previously reported the isolation of B2.1, a dimeric peptide that binds with high specificity to b12 and competes with gp120 for...

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Xehetasun bibliografikoak
Egile Nagusiak: Saphire, Erica Ollmann, Montero, Marinieve, Menendez, Alfredo, van Houten, Nienke E., Irving, Melita B., Pantophlet, Ralph, Zwick, Michael B., Parren, Paul W. H. I., Burton, Dennis R., Scott, Jamie K., Wilson, Ian A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2007
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1995417/
https://ncbi.nlm.nih.gov/pubmed/17445828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.01.060
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