CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration

The role of retinal microglial cells (MCs) in age-related macular degeneration (AMD) is unclear. Here we demonstrated that all retinal MCs express CX3C chemokine receptor 1 (CX3CR1) and that homozygosity for the CX3CR1 M280 allele, which is associated with impaired cell migration, increases the risk...

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Główni autorzy: Combadière, Christophe, Feumi, Charles, Raoul, William, Keller, Nicole, Rodéro, Mathieu, Pézard, Adeline, Lavalette, Sophie, Houssier, Marianne, Jonet, Laurent, Picard, Emilie, Debré, Patrice, Sirinyan, Mirna, Deterre, Philippe, Ferroukhi, Tania, Cohen, Salomon-Yves, Chauvaud, Dominique, Jeanny, Jean-Claude, Chemtob, Sylvain, Behar-Cohen, Francine, Sennlaub, Florian
Format: Artigo
Język:Inglês
Wydane: American Society for Clinical Investigation 2007
Hasła przedmiotowe:
Research Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994614/
https://ncbi.nlm.nih.gov/pubmed/17909628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31692
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