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Diversification of catalytic function in a synthetic family of chimeric cytochrome P450s
We report initial characterization of a synthetic family of more than 3,000 cytochrome P450s made by SCHEMA recombination of three bacterial CYP102s. Sixteen heme domains and their holoenzyme fusions with each of the three parental reductase domains were tested for activity on 11 different substrate...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1991292/ https://ncbi.nlm.nih.gov/pubmed/17379142 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.01.009 |
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