4-Hydroxyandrostenedione in the prophylaxis of N-methyl-N-nitrosourea induced mammary tumourigenesis.

We have examined the role of the aromatase inhibitor 4-hydroxyandrostenedione (4-OHA) in the prevention of mammary tumourigenesis in experiments involving 170 rats. We first demonstrated a prophylactic effect of 4-OHA (50 mg/week) in reducing tumour incidence over a 30 week period compared to contro...

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Bibliographic Details
Main Authors: Coombes, R. C., Wilkinson, J. R., Bliss, J. M., Shah, P., Easton, D. F., Dowsett, M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1991
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1977518/
https://ncbi.nlm.nih.gov/pubmed/1892751
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