The influence of high dose hydroxyurea on the incorporation of 5-iodo-2-deoxyuridine (IUdR) by human bone marrow and tumour cells in vivo.

Resistance to cytotoxics precludes the successful treatment of many solid tumours. Inhibition of DNA synthesis in normal tissues with antimetabolites such as hydroxyurea (HU) may be a useful means of improving the selective uptake of toxic thymidine analogues by the relatively resistant tumour cells...

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Autori principali: Philip, P. A., Kaklamanis, L., Carmichael, J., Tonkin, K., Morrison, H., Gatter, K., Harris, A. L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1993
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968348/
https://ncbi.nlm.nih.gov/pubmed/8471420
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