Highly Sensitive Method for Genomewide Detection of Allelic Composition in Nonpaired, Primary Tumor Specimens by Use of Affymetrix Single-Nucleotide–Polymorphism Genotyping Microarrays

Loss of heterozygosity (LOH), either with or without accompanying copy-number loss, is a cardinal feature of cancer genomes that is tightly linked to cancer development. However, detection of LOH is frequently hampered by the presence of normal cell components within tumor specimens and the limitati...

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Main Authors: Yamamoto, Go , Nannya, Yasuhito , Kato, Motohiro , Sanada, Masashi , Levine, Ross L. , Kawamata, Norihiko , Hangaishi, Akira , Kurokawa, Mineo , Chiba, Shigeru , Gilliland, D. Gary , Koeffler, H. Phillip , Ogawa, Seishi 
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Human Genetics 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950910/
https://ncbi.nlm.nih.gov/pubmed/17564968
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