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H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels
Specific stimuli such as intracellular H(+) and phosphoinositides (e.g., PIP(2)) gate inwardly rectifying potassium (Kir) channels by controlling the reversible transition between the closed and open states. This gating mechanism underlies many aspects of Kir channel physiology and pathophysiology;...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cell Press
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950231/ https://ncbi.nlm.nih.gov/pubmed/17698013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.07.026 |
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