H Bonding at the Helix-Bundle Crossing Controls Gating in Kir Potassium Channels

Specific stimuli such as intracellular H(+) and phosphoinositides (e.g., PIP(2)) gate inwardly rectifying potassium (Kir) channels by controlling the reversible transition between the closed and open states. This gating mechanism underlies many aspects of Kir channel physiology and pathophysiology;...

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Main Authors: Rapedius, Markus, Fowler, Philip W., Shang, Lijun, Sansom, Mark S.P., Tucker, Stephen J., Baukrowitz, Thomas
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950231/
https://ncbi.nlm.nih.gov/pubmed/17698013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.07.026
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