Image-Based Modeling Reveals Dynamic Redistribution of DNA Damage into Nuclear Sub-Domains

Several proteins involved in the response to DNA double strand breaks (DSB) form microscopically visible nuclear domains, or foci, after exposure to ionizing radiation. Radiation-induced foci (RIF) are believed to be located where DNA damage occurs. To test this assumption, we analyzed the spatial d...

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Bibliographic Details
Main Authors: Costes, Sylvain V, Ponomarev, Artem, Chen, James L, Nguyen, David, Cucinotta, Francis A, Barcellos-Hoff, Mary Helen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937017/
https://ncbi.nlm.nih.gov/pubmed/17676951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0030155
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