Effect of PF 10040 on PAF-induced airway responses in neonatally immunized rabbits.

1. PF 10040 displaced [3H]-PAF from binding sites on rabbit platelets with an IC50 = 1.07 x 10(-5) M, which was approximately three orders of magnitude below that of a standard PAF antagonist WEB 2086 (IC50 = 4.23 x 10(-9) M). 2. PF 10040 at doses of 5 and 10 mg (direct intratracheal administration)...

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Main Authors: Herd, C. M., Donigi-Gale, D., Shoupe, T. S., Kilfeather, S. A., Okiji, S. A., Page, C. P.
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1910040/
https://ncbi.nlm.nih.gov/pubmed/8012726
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