Exogenous type-1 cytokines modulate mercury-induced hyper-IgE in the rat

Suppression of IgE responses is a major goal for immunotherapy, especially in the field of allergy. The Th2 subset of helper T cells plays a vital role in class switching of B cells to IgE production by releasing IL-4. In susceptible rat strains, mercuric chloride (HgCl(2)) induces activation of Th2...

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Detalles Bibliográficos
Main Authors: Gorrie, M J, Qasim, F J, Whittle, C J, Gillespie, K M, Szeto, C-C, Nicoletti, F, Bolton, E M, Bradley, J A, Mathieson, P W
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2000
Assuntos:
Allergy
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905668/
https://ncbi.nlm.nih.gov/pubmed/10886234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2000.01261.x
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