Impact of bioavailability on determination of the maximal tolerated dose of 2',3'-dideoxyinosine in phase I trials.

The objective of this study was to determine the population pharmacokinetic parameters and the extent of absorption of 2',3'-dideoxyinosine, a nucleoside analog with activity against human immunodeficiency virus in vitro and in vivo, after oral and intravenous administration through the us...

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Main Authors: Drusano, G L, Yuen, G J, Morse, G, Cooley, T P, Seidlin, M, Lambert, J S, Liebman, H A, Valentine, F T, Dolin, R
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC190332/
https://ncbi.nlm.nih.gov/pubmed/1416828
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