Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation

Using fluorescence in situ hybridization we investigated amplification of chromosome band 1q21 (Amp1q21) in more than 500 untreated patients with monoclonal gammopathy of undetermined significance (MGUS; n = 14), smoldering multiple myeloma (SMM; n = 31), and newly diagnosed MM (n = 479) as well as...

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Bibliographic Details
Main Authors: Hanamura, Ichiro, Stewart, James P., Huang, Yongsheng, Zhan, Fenghuang, Santra, Madhumita, Sawyer, Jeffrey R., Hollmig, Klaus, Zangarri, Maurizio, Pineda-Roman, Mauricio, van Rhee, Frits, Cavallo, Federica, Burington, Bart, Crowley, John, Tricot, Guido, Barlogie, Bart, Shaughnessy, John D.
Format: Artigo
Language:Inglês
Published: © 2006 by The American Society of Hematology 2006
Subjects:
Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895503/
https://ncbi.nlm.nih.gov/pubmed/16705089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-009910
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