c-Rel plays a key role in deficient activation of B cells from a non–X-linked hyper-IgM patient

Our previous results demonstrated that B cells from a patient (pt1) with non–X-linked hyper-IgM syndrome (HIGM) possess an atypical CD23(lo) phenotype that is unaffected by CD40-mediated activation. To investigate the molecular mechanism underlying defective CD23 expression in pt1 B cells, we used l...

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Bibliographic Details
Main Authors: Lu, Kristina T., Sinquett, Frank L., Dryer, Rebecca L., Song, Charles, Covey, Lori R.
Format: Artigo
Language:Inglês
Published: The American Society of Hematology 2006
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895478/
https://ncbi.nlm.nih.gov/pubmed/16896156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-03-008839
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