JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome–negative CML, and megakaryocytic leukemia

An activating 1849G>T mutation of JAK2 (Janus kinase 2) tyrosine kinase was recently described in chronic myeloproliferative disorders (MPDs). Its role in other hematologic neoplasms is unclear. We developed a quantitative pyrosequencing assay and analyzed 374 samples of hematologic neoplasms. Th...

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Autores principales: Jelinek, Jaroslav, Oki, Yasuhiro, Gharibyan, Vazganush, Bueso-Ramos, Carlos, Prchal, Josef T., Verstovsek, Srdan, Beran, Miloslav, Estey, Elihu, Kantarjian, Hagop M., Issa, Jean-Pierre J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2005
Materias:
Clinical Trials and Observations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895065/
https://ncbi.nlm.nih.gov/pubmed/16037387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-1800
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