Sepiapterin reductase expression is increased in Parkinson’s disease brain tissue.

The PARK3 locus on chromosome 2p13 has shown linkage to both the development and age of onset of Parkinson’s disease (PD). One candidate gene at this locus is sepiapterin reductase (SPR). Sepiapterin reductase catalyzes the final step in the biosynthetic pathway of tetrahydrobiopterin (BH(4)), an es...

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Autori principali: Tobin, Jennifer E., Cui, Jing, Wilk, Jemma B., Latourelle, Jeanne C., Laramie, Jason M., McKee, Ann C., Guttman, Mark, Karamohamed, Samer, DeStefano, Anita L., Myers, Richard H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868471/
https://ncbi.nlm.nih.gov/pubmed/17270157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2007.01.001
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