Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats

The proliferation of myofibroblasts is a central feature of pulmonary fibrosis. In this study we have used tyrosine kinase inhibitors of the tyrphostin class to specifically block autophosphorylation of the platelet-derived growth factor receptor (PDGF-R) or epidermal growth factor receptor (EGF-R)....

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Main Authors: Rice, Annette B., Moomaw, Cindy R., Morgan, Daniel L., Bonner, James C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 1999
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1866660/
https://ncbi.nlm.nih.gov/pubmed/10393853
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