A structural snapshot of base-pair opening in DNA

The response of double-helical DNA to torsional stress may be a driving force for many processes acting on DNA. The 1.55-Å crystal structure of a duplex DNA oligonucleotide d(CCAGGCCTGG)(2) with an engineered crosslink in the minor groove between the central guanine bases depicts how the duplex can...

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Autors principals: van Aalten, Daan M. F., Erlanson, Daniel A., Verdine, Gregory L., Joshua-Tor, Leemor
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC18368/
https://ncbi.nlm.nih.gov/pubmed/10518532
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