Genetic deletion of p66(Shc) adaptor protein prevents hyperglycemia-induced endothelial dysfunction and oxidative stress

Increased production of reactive oxygen species (ROS) and loss of endothelial NO bioavailability are key features of vascular disease in diabetes mellitus. The p66(Shc) adaptor protein controls cellular responses to oxidative stress. Mice lacking p66(Shc) (p66(Shc−/−)) have increased resistance to R...

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Détails bibliographiques
Auteurs principaux: Camici, Giovanni G., Schiavoni, Marzia, Francia, Pietro, Bachschmid, Markus, Martin-Padura, Ines, Hersberger, Martin, Tanner, Felix C., Pelicci, PierGiuseppe, Volpe, Massimo, Anversa, Piero, Lüscher, Thomas F., Cosentino, Francesco
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1829289/
https://ncbi.nlm.nih.gov/pubmed/17360381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609656104
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