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Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine

Neuronal adaptations in striatal dopamine signaling have been implicated in enhanced responses to addictive drugs. Cyclin-dependent kinase 5 (Cdk5) regulates striatal dopamine signaling and is a downstream target gene of the transcription factor ΔFosB, which accumulates in striatal neurons after chr...

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Autors principals: Taylor, Jane R., Lynch, Wendy J., Sanchez, Hayde, Olausson, Peter, Nestler, Eric J., Bibb, James A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820723/
https://ncbi.nlm.nih.gov/pubmed/17360491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610288104
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