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Restriction of endogenous T cell antigen receptor β rearrangements to Vβ14 through selective recombination signal sequence modifications

T cell antigen receptor (TCR)β V(D)J variable region exon assembly is ordered, with Dβ to Jβ rearrangements occurring before joining of Vβs to a DJβ complex. Germ-line V(D)J segments are flanked by recombination signal (RS) sequences, which consist of heptamers and nonamers separated by a spacer of...

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Auteurs principaux: Wu, Cherry, Ranganath, Sheila, Gleason, Megan, Woodman, Barbara B., Borjeson, Tiffany M., Alt, Frederick W., Bassing, Craig H.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1820698/
https://ncbi.nlm.nih.gov/pubmed/17360467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700081104
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