Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL‐induced apoptosis

BACKGROUND: Histone acetylation/deacetylation has a critical role in the regulation of transcription by altering the chromatin structure. OBJECTIVE: To analyse the effect of trichostatin A (TSA), a streptomyces metabolite which specifically inhibits mammalian histone deacetylases, on TRAIL‐induced a...

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Библиографические подробности
Главные авторы: Jüngel, A, Baresova, V, Ospelt, C, Simmen, B R, Michel, B A, Gay, R E, Gay, S, Seemayer, C A, Neidhart, M
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Group 2006
Предметы:
Extended Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1798225/
https://ncbi.nlm.nih.gov/pubmed/16284094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2005.044065
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