Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition

Dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32), encoded by PPP1R1B, is a pivotal integrator of information in dopaminoceptive neurons, regulating the response to neuroleptics, psychotomimetics, and drugs of abuse, and affecting striatal function and plasticity. Des...

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Autors principals: Meyer-Lindenberg, Andreas, Straub, Richard E., Lipska, Barbara K., Verchinski, Beth A., Goldberg, Terry, Callicott, Joseph H., Egan, Michael F., Huffaker, Stephen S., Mattay, Venkata S., Kolachana, Bhaskar, Kleinman, Joel E., Weinberger, Daniel R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1784004/
https://ncbi.nlm.nih.gov/pubmed/17290303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30413
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