Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins

Chromosomal translocations involving the N-terminal ≈250 residues of the Ewings sarcoma (EWS) oncogene produce a group of EWS fusion proteins (EFPs) that cause several distinct human cancers. EFPs are potent transcriptional activators and interact with other proteins required for mRNA biogenesis, in...

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Hlavní autoři: Ng, King Pan, Potikyan, Gary, Savene, Rupert O. V., Denny, Christopher T., Uversky, Vladimir N., Lee, Kevin A. W.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2007
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766410/
https://ncbi.nlm.nih.gov/pubmed/17202261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0607007104
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