Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

Autophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. Whether autophagy observed in treated cancer cells represents a mechanism that allows tumor cells to survive therapy or a mechanism for initiating a nonapoptotic form of...

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Autors principals: Amaravadi, Ravi K., Yu, Duonan, Lum, Julian J., Bui, Thi, Christophorou, Maria A., Evan, Gerard I., Thomas-Tikhonenko, Andrei, Thompson, Craig B.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2007
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1765515/
https://ncbi.nlm.nih.gov/pubmed/17235397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28833
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