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Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans.
MICs of clarithromycin and its major human metabolite, 14-hydroxy-clarithromycin, for Haemophilus influenzae in combination were reduced two- to fourfold compared with the MICs of each compound alone. Serum reduced the MICs of the parent compound and metabolite two- to fourfold compared with the MIC...
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Main Authors: | , , , , , |
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格式: | Artigo |
語言: | Inglês |
出版: |
1990
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC175991/ https://ncbi.nlm.nih.gov/pubmed/2143642 |
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