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The MLCK-mediated α(1)-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCɛ signaling
1. The present study examined the role of myosin light chain kinase (MLCK), PKC isozymes, and inositol 1,4,5-trisphosphate (IP(3)) receptor in the positive inotropic effect of α(1)-adrenergic stimulation in atrial myocardium. 2. We measured inotropic effects of phenylephrine (0.3–300 μM) in isolated...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2006
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1751924/ https://ncbi.nlm.nih.gov/pubmed/16783412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706803 |
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